Mercredi 20 juillet 2011

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guccioutlet  Brentuximab vedotin, whichSeattle Genetics will market as Adcetris, combines an antibody with achemotherapy drug to treat the rare blood cancer in a novel way. The antibodybinds to the CD30-positive Reed-Sternberg cells that are characteristic of thedisease, while the drug -- monomethyl auristatin -- then attacks the internalstructure of the cells.The Oncologic Drugs Advisory Committee based its 10-0vote on the Hodgkin lymphoma indication on the company's open-label trial in whichthree-quarters of the patients treated with brentuximab vedotinhad at leastsome reduction in tumor burden and more than a third had a complete remission.

The trial involved 102 patients, median age31, who had previously failed an autologous stem cell transplant. Patients hada median of four previous chemotherapy regimens and some had had as many as 13previous regimens.Patients were given 1.8 mg/kg of brentuximab vedotin everythree weeks for up to 16 cycles as a 30‑minute outpatient intravenous infusion.The primary endpoint was the overall objective response rate, which was75%.More than one-third of patients had complete remission, and 40% had partialremission. Overall, 94% patients had at least some tumor reduction.

  guccishoes Later in the day, the advisory committee again voted 10-0 that thedrug should also be approved for relapsed or refractory systemic anaplasticlarge cell lymphoma (ALCL).The company's ALCL trial involved 58 patientsbetween the ages of 18 and 64. They were given 1.8mg/kg of brentuximab vedotinintravenously every 21 days for up to 16 cycles.In that trial, 86% of patientsachieved the primary endpoint -- objective response -- and 57% had a completeremission. The median duration of the complete remission was 13.2 months.Themain adverse event with brentuximab vedotin was peripheral neuropathy. Fatigueand nausea were also common.

There have been no new agents approved forthe treatment of Hodgkin lymphoma since 1977 and there are no standard orapproved therapies for patients who are refractory or relapsed after stem celltransplant.The FDA is not required to follow the advice of its advisorycommittees, but it often does.If Seattle Genetics receives acceleratedapproval, it still has to perform a trial confirming that the drug works and issafe.

Par wangcx84004 - 0 commentaire(s)le 20 juillet 2011

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louis vuitton outlet Had thebank not restated that number, the jump would have been 62%. The bank alsorevised the totals upward for several other quarters in 2010. The bank said ina footnote that the additions represent securities held by private investors,as opposed to government-controlled mortgage companies Fannie Mae or FreddieMac. The bank left the claims out of previous filings because it thought itmight fight the repurchases, said a person familiar with the situation.

A J.P. Morgan spokesman said the previousways of handling the number were appropriate and "the change reflected thefirm's current views on how the loan demands would be resolved."

Despite J.P. Morgan's many mortgageproblems, there are signs that lending is beginning to turn around in certainsectors. The bank's total loans dropped 1% but the commercial-banking unitreported a 6% rise in average loans, a sign that companies are slowly taking onmore credit to fund inventory and capital improvements.

Consumers and businesses also aredefaulting less on loans. The credit-card division was able to release $1billion from its loan-loss reserves, and the unit's profits nearly tripled. Theamount of credit-card loans written off as uncollectable dropped to 5.8% ascompared with 10.2% a year ago. The bank expects that rate to fall to 4.5% inthe third quarter.

But the standout for J.P Morgan in thequarter was its investment bank, where profits climbed 49% and revenue rose16%. Debt and equity underwriting fees were up 24% and 29%, respectively, whilefees for advising companies on deals soared 69% as the bank closed on certaintransactions agreed to in prior quarters.

  cheaplouis vuitton Analysts said the gains show J.P. Morgan is using its hugebalance sheet and broad reach to grab market share while other competitors licktheir wounds."I think they really have figured out how to make theuniversal bank model work for them," said Moshe Orenbuch, managingdirector at Credit Suisse Securities LLC. "They have certainly set the barhigh." simply the best free music service out there today -- unless youjust want to be entertained, rather than putting a bit of effort intoentertaining yourself.Launched in the U.S. this week, Spotify is one of just ahandful of services that have tried to build a business around offering songson demand for free. Unlike ill-fated SpiralFrog, it provides streams, notdownloads. And unlike Lala, which was snapped up and shuttered by Apple, userscan play songs multiple times, not just once.



Par wangcx84004 - 0 commentaire(s)le 20 juillet 2011

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burberry outlet “Therewas a heyday of comedies on cable like ‘Sex and the City,’ but now it’sbroadcast” that dominates the genre for Emmy voters, said Tom O’Neil, editor ofthe award websites and“Modern Family,” crownedbest comedy series after its freshman season, received 17 nominations this timearound.“OK, keep it together,” Plainfield native Melissa McCarthy said Thursdaywhile announcing the nominations and realizing she was in the running herselffor “Mike & Molly.”Another local, former Oak Parker Johnny Galecki of “TheBig Bang Theory,” scored his first nomination. “I gotta call my mother,” hesaid, “and have a mimosa and a nap, not necessarily in that order.”

Given broadcasters’ fixation onstraightforward crime dramas such as “CSI”and “NCIS,” it’s unsurprising thatcable’s more daring series dominate the Emmys.Besides handing AMC’s “Mad Men”19 nominations and a shot at a fourth consecutive best drama series trophy, theacademy gave fistfuls of bids to HBO’s wild Prohibition-era series “BoardwalkEmpire” (18) and fantasy saga “Game of Thrones” (13).The melodrama “MildredPierce,” starring Kate Winslet and based on the 1941 James M. Cain novel,grabbed a top 21 bids including best miniseries or movie in the new categorythat combines both formats.Also in the category is the miniseries “TheKennedys,” which was dropped by the History channel and given a second chanceby lesser-known ReelzChannel. The Emmy Awards are scheduled to air Sept. 18 onFox, with “Glee” star and nominee Jane Lynch hosting.

burberry scarf Atthe end of a first round that began gray and windblown and ended sunny andcalm, hours after Thomas Bjornof Denmark had shot a five-under-par 65 to top aleader board loaded with Europeans, the 20-year-old English amateur Tom Lewismatched Bjorn’s 65 and became the first amateur to gain a share of the BritishOpen lead since Sir Michael Bonallack in 1968 at Troon.

The floodgates have been flung wide open.It may be way too early for 22-year-old Rory McIlroy to be hearing thefootsteps of younger players, but for one day, as the poised and polished Lewisdiscussed his round in the media center, McIlroy may have been feeling a littleless sanguine about his routine round of one-over-par 71. It was a startlingshow by Lewis, who was playing with Tom Watson, the man his father named himafter. It also was an appropriate bookend to a day that first belonged toBjorn, 40, who only got into the field on Monday as the sixth alternate afterVijay Singh withdrew.


Par wangcx84004 - 0 commentaire(s)le 20 juillet 2011
Mardi 19 juillet 2011

The fashion of the prada outlet gucci outlet Vultures have been implicated in controlling rabies

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gucci outlet  Vultures have been implicated in controllingrabies and anthrax and predatory fish in controlling malaria and allowing lakesto soak up more carbon dioxide through similar mechanisms, the researchersreport. They list more. "They put them all together in one place and allof a sudden it's an eye-opener and you say, 'Oh my god, look at this,'"Kareiva said.  As some of these examples highlight, reintroducing toppredators reverses the changes caused by their loss. "The world can befixed in many cases. I think that's the good news," said study lead authorJim Estes.

On the other hand, sometimes the changesare a one-way street and the systems change in ways that prevent recovering tothe same point, even if the top-of-the-food-chain animals are reintroduced."I'm not proposing that we reintroduce big predators to the wholeworld," Estes added. "I think the point of this is that we need tothink about these things as we think about the whole future of the world andhow we manage our resources."

For one thing, the findings suggest adifferent way of looking at conservation. "For the last 20 years, much ofconservation has focused on biodiversity hotspots," Kareiva said."That means you make an inventory of what lives in a place and you protectplaces that have the most species living in them."

  guccishoes The new paper suggests anew approach might work better, he said. "The issue is not where do themost species live, but what are the apex consumers and what do they need tosurvive." HOUSTON – The shuttle Atlantis' astronauts were roused fromtheir sleep tonight (July 14) to deal with a glitch that affected one of theirorbiter's onboard computers. The spaceflyers were able to successfully transferthe computer's programs onto a backup, and will get some extra time to sleep intomorrow as a result.The shuttle astronauts were awakened by an alert tone at6:07 a.m. EDT (2207 GMT), signaling a failure with one of Atlantis' GeneralPurpose Computers (GPCs). The glitchy computer runs Atlantis' systemsmanagement and mission controllers walked shuttle commander Chris Fergusonthrough the process of transferring its programs onto one of the shuttle'sbackups.The space shuttle carries five onboard computers for redundancy, withone always designated asa backup. The four other computers work together tomake up the orbiter's primary computer systems, NASA officials said. [Photos:NASA's Last Shuttle Mission in PicturesDuring non-critical times on orbit, theshuttle typically operates using two f the four available primary workstations.


Par wangcx84004 - 0 commentaire(s)le 19 juillet 2011

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louis vuitton outlet  "That should change how we invest ourmoney, how we manage, what we do. Instead of blindly protecting all species wecould go after those really important ones," he said. "What thisarticle highlights are some new discoveries that the loss of predators or theloss of large herbivores can lead to wholesale transformation of ecosystems andthe way they function," said Oswald Schmitz of Yale University, who wasalso not a part of the new study, published today in the journal Science."That's a paradigm-changing way to look at things."  At the sametime "Predators are disproportionately vulnerable to human impacts becausethey need large spaces," he said. "We're in a quandary right nowbecause we're making all these new scientific discoveries about predators, andat the same time we're losing them faster than many other species."

A team of about 20 leading ecologistsgathered examples from land and sea worldwide to make their point. Here aresome of the examples. In Yellowstone National Park, where wolves'delisting as an endangered species remains a contested issue, researchersfound that in the absence of wolves, elk increase in number and begin to grazewithout fear of predation, damaging the shores of streams and changing theircourses.They prevent aspen and willow seedlings from taking hold and reduce theshady habitat needed for stream fish to thrive. Reintroducing wolves hasbrought back young aspen and allowed willow saplings to take hold along streambeds in the park, which provides habitat for beavers, songbirds and fish.

  cheaplouis vuitton Meanwhile, in the Pacific Ocean, sea otters allow kelpforests and the mussels and fish that live nearby to thrive by keeping seaurchins from overgrazing the kelp.In an example from Africa, the researcherspoint to rinderpest, a viral disease also known as "cattle plague,"which decimated populations of wildebeest and buffalo. Without these largeherbivores, vegetation overgrew the area, turning grasslands into shrublandsand leading to more frequent, more intense wildfires. An extensive controlprogram eradicated rinderpest from East Africa in the 1960s, and wildebeestlevels returned to what is thought were their earlier levels by the 1980s,changing the landscape back and decreasing fires again.Also in Africa, the lossof lions and leopards has boosted populations of olive baboons who then come ingreater contact with humans, seeking food. This increased contact has led toincreases in intestinal parasites in both the baboons and the people livingnear them.



Par wangcx84004 - 2 commentaire(s)le 19 juillet 2011

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burberryoutlet  Since October 2008, the NBAand its teams have reduced headcount by nearly 400 — including the 114 in thepast two days — through layoffs and vacated positions left unfilled.The leaguesaid it lost nearly $350 million in 2009-10 and nearly $300 million lastseason. The job reductions underscore the league's financial woes at a timewhen it is trying to drastically alter the collective bargaining agreement withplayers.The NBA and owners want a bigger share of revenue in an attempt torestore profitability, but players say they are asking for too much. The sidesremain far apart. No formal bargaining session is scheduled, but the league andNational Basketball Players Association remain in contact.DENVER -- FranciscoRodriguz says he's fine with being traded to the Milwaukee Brewersdespitepreviously indicating he did not want to be dealt to the club.

When Rodriguez signed with the New YorkMets after the 2008 season he and his former agent, Paul Kinzer, created a listof 10 teams he did not want to be traded to, and Milwaukee was on that list.Rodriguez said his agent never sent the letter to the players association ormajor league baseball.

burberryscarf "I'm still trying to find out what happened. I was told by myex-agent about the 10-team list and Milwaukee was one of them," Rodriguezsaid. "When I got the phone call from the GM and told I was traded I was alittle confused. I just found out my agent never sent the letter to the playersassociation or MLB. The Mets had an opportunity to trade me to any place."Rodriguezsaid Milwaukee was on the list because it had an established closer in TrevorHoffmanho has since retired."That was my No. 1 reason. At that timeHoffman was here," he said. "That's not an issue at all. I'm a Brewernow. I just want to win."The Mets sent Rodriguez and cash to the Brewerson Tuesday night for two players to be named. The Mets' first-year generalmanager Sandy Alderson said Thursday in New York he told Rodriguez's formeragent there was no list.

"We proceded with the trade market onthat basis," Alderson said. "I had discussions with the former agentsin the last two or three weeks and we made them aware that as far as we knewthere was no list."

Rodriguez said he had heard rumors he mightbe traded but he was taken aback by Tuesday's deal.

Par wangcx84004 - 1 commentaire(s)le 19 juillet 2011

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